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Causes Of Gerd
By Jack Smith
A number of conditions are believed to cause GERD. Different conditions may be active in different individuals, or even the same individual at different times. Chief among these are:

Lower Esophageal Sphincter (LES)
The esophagus is a muscular tube extending from the lower part of the throat to the stomach. At its lower-most end, where it joins the stomach, it has a muscular ring called the LES. It is the proper functioning of the LES that is most important in preventing reflux. The LES muscle is active almost continuously. In order to prevent reflux, it contracts and thus blocks off the passage from the esophagus to the stomach. After a swallow (of food or saliva), it relaxes for several seconds, thus allowing the food to pass from the esophagus to the stomach, and then contracts again.

In patients with GERD, two abnormalities of the action of the LES can occur. The first is when its contraction is weaker than normal, thus allowing reflux to happen more easily. The second is when its relaxations last longer than normal. These are called transient relaxations. These also cause reflux to occur more easily, especially after meals, when the stomach is distended with food.

Hiatal Hernia
In a normal person, the LES is located at the same level where the esophagus passes from the chest through the diaphragm and into the abdomen. In case of hiatal hernia, a small part of the stomach is pushed up through the diaphragm. As a result, the LES is no longer at the same level as the diaphragm – a small part of the LES and stomach lie in the chest.

Normally, the combined pressure that is exerted by

Stomach Wraps Effective In Short To Medium Term For Severe Acid Reflux
Stomach wrap operations may be more effective than acid suppression tablets in the treatment of severe acid reflux, according to a new Cochrane Systematic Review. The study shows a more pronounced improvement in symptoms shortly after surgery than with drug treatment...
Anti-Hypertensive Drugs To Enhance Esophageal Contraction
Nifedipine, a calcium-channel blocker, was shown to decrease lower esophageal sphincter pressure and increase esophageal acid exposure time, while atenolol, a b1 blocker, was shown to inhibit relaxation of the smooth muscle of the esophagus...
New Endoscopic Treatment May Spare Barrett's Esophagus Patients From Surgery
Early tumor formation in Barrett's esophagus (BE) can be effectively and safely treated with radiofrequency ablation (RFA), in combination with prior endoscopic removal of visible lesions, according to a new study in Clinical Gastroenterology and Hepatology, the official journal of the American Gastroenterological Association (AGA) Institute...
Shape Of Barrett's Epithelium Effects Prevalence Of Erosive Esophagitis
Barrett's epithelium is recognized as a complication of erosive esophagitis and is the pre-malignant condition for adenocarcinoma of the esophagus. A research team from Yokohama City University School of Medicine hypothesized that some macroscopic features of Barrett's epithelium might be useful for identifying a subgroup with a high risk for the development of esophageal adenocarcinoma...
New Hope For Therapy In Heartburn-Related Cancer
Cancer of the gullet, or oesophagus, is one of the ten most common cancers in the Western world, and there have been recent alarming increases in the number of cases each year in the US and UK. There is no good treatment, and sufferers frequently face a short, painful battle which ends all too quickly in death. Many of the cancers diagnosed are in people with a long history of heartburn...
Development Of ADX10059 Ended For Long-Term Use
Addex Pharmaceuticals (SWISS: ADXN) announced that based on preliminary review of the unblinded data from study 206, it has terminated development of ADX10059 for chronic indications, including long term treatment of gastroesophageal reflux disease and migraine prophylaxis...
Amneal Receives FDA Approval For Nizatidine Oral Solution, The First Generic Oral Solution For Axid(R) In The Market
Amneal Pharmaceuticals is pleased to announce that it has received U.S. FDA approval to manufacture Nizatidine Oral Solution in the 15 mg/mL strength effective November 18, 2009. It is an AA-rated, therapeutically equivalent alternative to Axid® Oral Solution (a licensed trademark of Braintree Labs)...
Are Manometric Findings Different Between Patients With Erosive And Nonerosive Disease?
Gastroesophageal reflux disease (GERD) is defined as the pathological retrograde movement of gastric contents into the esophagus. Various esophageal motility disturbances which may be important in reflux are observed in patients with GERD. The main esophageal motility disorder in these patients is ineffective esophageal motility (IEM)...
Why Does Percutaneous Endoscopic Gastrostomy Fail To Eliminate Gastroesophageal Reflux?
Gastroesophageal reflux (GER) is a common problem in mechanically ventilated patients and contributes to the development of esophageal mucosal injury and even erosive esophagitis. The relationship between percutaneous endoscopic gastrostomy (PEG) and subsequent development of GER is complex and not well understood...
Strengthening Sphincters In Animals Via Muscle Cell Infusion
A new study shows that muscle cells grown in the lab can restore an intestine's ability to squeeze shut properly. The work, performed in dogs and rats, might ultimately help treat patients with conditions such as gastric reflux and fecal incontinence. This technique may be used to strengthen sphincters, which are the bands of muscle that separate the major sections of your intestinal tract...
FDA Approves ZEGERID OTC(TM) For Over-the-Counter Treatment Of Frequent Heartburn
Merck & Co., Inc. announced that the U.S. Food and Drug Administration (FDA) has approved ZEGERID OTC(TM) (omeprazole 20 mg/sodium bicarbonate 1100 mg capsules), for over-the-counter treatment of frequent heartburn. ZEGERID OTC will be marketed over-the-counter by Schering-Plough HealthCare Products, Inc., the consumer healthcare division of Merck & Co., Inc...
News From The November Issue Of GIE: Gastrointestinal Endoscopy
"Screening for Barrett's esophagus in asymptomatic women" Barrett's esophagus is a condition where the lining of the esophagus changes due to chronic inflammation, generally from gastroesophageal reflux disease (GERD). Barrett's esophagus is important to recognize as it may increase the risk of developing esophageal cancer...
Reflux Esophagitis Due To Immune Reaction, Not Acute Acid Burn
Contrary to current thinking, a condition called gastroesophageal reflux disease (GERD) might not develop as a direct result of acidic digestive juices burning the esophagus, UT Southwestern Medical Center researchers have found in an animal study. Rather, gastroesophageal reflux spurs the esophageal cells to release chemicals called cytokines, which attract inflammatory cells to the esophagus...
Addex ADX10059 Monotherapy Is Effective On GERD Symptoms In Phase IIb Clinical Trial
Addex Pharmaceuticals (SWISS: ADXN), the allosteric modulation company, announced that it achieved statistically significant efficacy on the primary endpoint, increasing the number of symptom free days in the Phase IIb trial of ADX10059 as a monotherapy in patients with gastroesophageal reflux disease (GERD), the cause of heartburn and other symptoms...
Mylan Receives FDA Approval For Generic Version Of Prevacid® Through Its Subsidiary Matrix Laboratories
Mylan Inc. (NASDAQ: MYL) announced that its privately held Indian subsidiary, Matrix Laboratories Limited, has received final approval from the U.S. Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) for Lansoprazole Delayed-release (DR) Capsules, 15 mg and 30 mg. This product is shipping immediately and will be sold under the Mylan Pharmaceuticals brand...
Open Wide: Incisionless Surgery To Treat GERD
Every day, more than 20 percent of the U.S. population experiences the painful burning symptoms of gastroesophageal reflux disease (GERD). For these 20 million Americans, the first line of defense is medication...
FDA Approves New Salix Product Exclusively In Catalent's Zydis(R) Fast Dissolve Technology
Catalent Pharma Solutions, one of the leading advanced drug delivery technology providers to the pharmaceutical industry, announced that the U.S. Food and Drug Administration (FDA) has granted marketing approval for Metozolv™ ODT (orally disintegrating tablets) metoclopramide HCL utilizing Catalent's Zydis® fast dissolve technology...
Unexpected Consequences Of Proton Pump Inhibitor Use In Reflux Disease
Despite being highly effective and beneficial for many patients, unexpected consequences are emerging in patients who are prescribed proton pump inhibitors (PPIs) for reflux diseases. Physicians are warned to monitor these effects and prescribe these medications carefully, according to a new commentary published in the November 2009 issue of Otolaryngology -Head and Neck Surgery...
New Procedure For Acid Reflux/GERD
Boston Medical Center (BMC) surgeons are now offering patients an incisionless alternative to laparoscopic and traditional surgery for treatment of acid reflux or GERD. Using the new procedure known as EsophyX TIF (Transoral Incisionless Fundaplication), surgeons can repair or reconstruct the valve between the esophagus and stomach, effectively stopping GERD...
New Studies Explore Connection Between High Stress And High Exposure Jobs And GI Disorders
In two new studies, presented at the American College of Gastroenterology's (ACG) 74th Annual Scientific meeting in San Diego, researchers explored the connection between high stress, high exposure occupations and long-term gastrointestinal disorders...
New Study Results Analyzed The Use Of KAPIDEX(TM) (dexlansoprazole) For Nighttime Heartburn In Adults With Non-Erosive GERD
New data being presented at the American College of Gastroenterology (ACG) 2009 Annual Scientific Meeting in San Diego showed that treatment with KAPIDEX(TM) (dexlansoprazole) delayed release capsules over a four-week period resulted in a statistically significant greater percentage of nights without heartburn in subjects with non-erosive gastroesophageal reflux disease (GERD),...
Possible Weight-Gain From Long-Term Treatment With Proton Pump Inhibitor
Gastroesophageal reflux disease (GERD) is the most common esophageal disorder, and frequently encountered in the primary care setting. Accumulating evidence has confirmed the excellent efficacy and safety of proton pump inhibitor (PPI) therapy in patients with all grades of GERD, making these agents the mainstay of treatment...
XenoPort Announces Initiation Of A Phase 2b Clinical Trial Of Arbaclofen Placarbil In Patients With Gastroesophageal Reflux Disease
XenoPort, Inc. (Nasdaq:XNPT) announced today that it has initiated a Phase 2b clinical trial of arbaclofen placarbil (AP), also known as XP19986, in patients with gastroesophageal reflux disease (GERD) who remain symptomatic despite treatment with a proton pump inhibitor (PPI)...
Heartburn Drugs Deemed Safe For Fetuses According To Ben-Gurion University Researchers
H2 Blocker drugs, such as Famotidine, Cimetidine and Ranitidine, approved in the U.S. for acid reflux (heartburn), pose no significant risks for the fetus according to a large collaborative cohort study by researchers at Ben-Gurion University of the Negev...
Addex Completes Enrollment Of First Mid-Stage Clinical GERD Trial
Addex Pharmaceuticals (SWISS: ADXN), the allosteric modulation company, announced the completion of enrollment in the Phase IIb trial of ADX10059 as a monotherapy in patients with gastroesophageal reflux disease (GERD), the cause of heartburn and other symptoms...

the diaphragm and the LES help to prevent reflux. With a hiatal hernia, both the LES and diaphragm continue to exert pressure and thus block off reflux, but they do so at different locations. Hence, the pressure exerted is weaker because it no longer has the combined strength of both. This causes reflux to occur more easily.

Esophageal contractions
Swallowing contributes significantly to the removal of acid from the esophagus. When we swallow, waves of contractions begin to travel down the esophagus, pushing along with it the food and saliva from the esophagus to the stomach.

A defect in the wave of contractions renders ineffective the pushing back of acid into the stomach. Sometimes, the wave may not begin after each swallow or may fade out before reaching the stomach. The pressure generated by the contractions may be too weak to be effective.

Prolonged Emptying of the stomach
The stomachs of some patients with GERD empty slower than normal after a meal. This prolongs the distention of the stomach after a meal. Hence, there is more time for reflux to occur.

Jack Smith writes about tons of great topics including acid reflux, GERD, and heartburn. This article is free to re-print as long as nothing is changed, all links remained intacked, the bio remains in full and the rel="nofollow" tag is not added to any of the links. Thank-you Please Visit Acid Reflux Information


 
 
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Natural remedies used to lower high cholesterol levels are not only safe but also very effective. A healthy diet and regular exercise are the best natural remedies for high cholesterol. Reports show that they can lower cholesterol levels by 35% in weeks and with a combination of natural supplements the cholesterol levels are greatly reduced. The liver produces most of the cholesterol in our bodies and is used for certain functions in our bodies however too much of it is harmful.
Tips That Can Help Lower Cholesterol Levels
The liver produces most of the cholesterol in our bodies and therefore it is important that we keep to healthy diet of vegetables, fresh fruits and regular exercise on a daily basis. There are two types of cholesterol levels in our bodies, low density lipoproteins (LDL), this are bad cholesterol levels and the high density lipoproteins (HDL) which are the good cholesterol levels.
Contents of Diets That Control High Cholesterol
Reports show that approximately 65% of all heart diseases are due to high cholesterol levels in the body and the reason why people have high cholesterol levels is because they do not eat enough healthy foods and they are constantly stuffing themselves with foods that have large amounts of saturated fats. These fats are very harmful for they increase the levels of the bad cholesterol in your body, that is, your low density lipoproteins (LDL). High LDL levels cause a blockage to the arteries which leads to a heart attack.
How Do You Raise HDL Values
How do you raise HDL values is a question that more and more people are starting to ask as the relationship between high cholesterol and heart disease continues to strengthen. In this informational article titled "How Do You Raise HDL Values" we will work to explain why learning how to be smart about cholesterol could literally save your life.
How to Increase HDL Levels - The Sheriff Needs a Few Good Men
Cholesterol numbers can be tricky to figure out with a list a mile long of risk factors for a heart attack to factor in or factor out. Risk factors such as age, gender, family history, obesity, and good and bad cholesterol readings all play a major role and can vary a great deal from person to person. But one area seems to be a constant and that is the area of good cholesterol or HDL.
How to Raise HDL Levels - Adapt, Adopt, and Succeed
Cholesterol is a wax like substance that can build up in the walls of our arteries. As the cholesterol continues to accumulate on the walls of our arteries the arteries start to lose the ability to expand and contract, thus leading to a condition know atherosclerosis or hardening of the arteries.
How to Quickly Stop Heartburn Pains - Simple Things You Can Start Doing Today to Get Relief
It's a well known fact that heartburn can cause a lot of pain and discomfort. Currently there are a number of different medications a person can use to get some relief from heartburn pains. However, medications are not always the best way to deal with these heartburn pains for some people.
Romance Your Heart Health to Eliminate Cardiovascular Disease
We often say to put a little heart in it, in everything we do because it truly makes a difference. But, what are you doing in return for your heart? While we are living longer, heart failure is advancing in people over the age of 65. If you want a long, healthy life, it's important to begin now, in protecting your heart!
Heart Disease Risks and Prevention
There are many factors to take into consideration with heart disease. One of the most common types is coronary artery disease. It is also referred to as arteriosclerosis. There are ways to recognize and prevent this frequent killer. Here are some things to take into consideration.
Heart Attacks and Job Loss
A recent article in the New York Times of February 24, 2010, entitled At Closing Plant, Ordeal Included Heart Attacks brings to light a problem that may not go away soon. If you lost your job, or if your job is not secure, you may understandably be under a lot of stress, which may have significant health consequences.
A Comparison of Using Drugs and Natural Means to Lower Cholesterol
Individuals who have high cholesterol problems are spoilt for choice because of the availability of cholesterol treatment alternatives available in the market. It would be ridiculous to suffer a heart attack caused by high cholesterol levels in your body while there are ways to combat the problem. Certain doctors will recommend that you use natural remedies, however if your cholesterol levels are dangerously high, the doctor will recommend that you ingest cholesterol drugs with a combination of natural cholesterol supplements.
How Do I Increase My HDL? Five Simple Ideas to Increase HDL
With more and more evidence piling up confirming the idea that certain types of cholesterol reduce the chances of both heart attack and stroke it is no wonder so many people are wanting to know how do I increase my HDL. HDL stands for high density lipoproteins and are often simply referred to as good cholesterol.
A Low Cholesterol Diet
What is Cholesterol? Cholesterol is a fat that borders in the cells in the body of animals. Cholesterol is also found in the blood of humans.
HDL Reading - A Couple of Important Facts Worth Learning More About
You just finished a couple of chili cheese dogs, haven't exercised in a while, and need to catch that last minute smoke to satisfy your nicotine craving. You know your last HDL reading was really low but you figure that living life to its fullest is much more important than those silly cholesterol numbers. After all the lab probably got your lipoprotein profile mixed up with someone else.
High Cholesterol - Hypercholesterolemia
Cholesterol is a waxy steroidal metabolite mostly found in the cell membranes and it is transported in the blood plasma of all mammals. It is an essential structural component of cell membranes in mammals. Cholesterol is required to establish proper membrane permeability and fluidity.
High Cholesterol Causing Risk Factors and Screening Test
High cholesterol has no known sign and symptoms. Cholesterol is more common among those who have a family history of high cholesterol or improper lifestyle such as eating fat rich diet & low physical activity.
Sugary Fruit Juice to Increase Risk of Heart Disease - How Fructose Can Kill You
If you are on the heavy side, sugary drinks like fructose-rich fruit juices must be avoided, these drinks may increase your risk of heart disease. This is the new finding in a study at University of California at Davis. Read this article if you are a fruit juice fanatic and learn how fructose can actually kill you.
Cholesterol, Saturated Fats, & Heart Disease - Confusion and Misinformation
Physicians and The American Heart Association have been saying for decades that eating saturated fats causes heart disease and cardiovascular disease. Recent studies show that there is no significant evidence for concluding that dietary saturated fat is associated with an increased risk of coronary heart disease or cardiovascular disease.
Improving Your Cholesterol Levels With Your Diet
Taking the time and initiative to improve your cholesterol levels with your diet will be well worth it in the long run. By changing your diet you rely less on your exercise level to keep you healthy.
Why Invest in Acid Reflux Pillows?
For individuals suffering from heartburn, a number of possible treatment and prevention options are now available and the list includes acid reflux pillows. Learn more by reading on.
Discover How the Omega 3 Effect on Cholesterol Levels Can Help Keep Your Heart Healthy
You have probably heard about Omega 3 and its properties that help you fight heart disease, but do you really understand how it works? In order to help you get a better grip on this issue, this article is going to explain the basic omega 3 effect on cholesterol levels to you. Heart disease is linked to high level of cholesterol in the body.
Causes of High Cholesterol and Ways to Lower it Naturally
High cholesterol is a problem that is caused by the lack of a proper healthy balanced diet, bad eating habits and in some cases it is hereditary. Certain individuals inherit the condition familial hypercholesterolemia, a condition where the cholesterol levels are dangerously high. In other cases, the individuals tend to eat a lot of foods that contain high cholesterol or a lot of saturated fats which will basically increase your low density lipoproteins levels (LDL), that is, your bad cholesterol which is a health risk that causes a blockage to your arteries and subsequently causing heart disease among other ailments.
A Comparison of Cholesterol Drugs
Scientific research has discovered various cholesterol treatment alternatives and doctors have over the years recommended to patients who have undergone cholesterol screening and found out that their cholesterol levels are dangerously high to use various cholesterol drugs that are available. The market offers various drugs, namely, statins, niacin, bile acid sequestrants and fibric acid derivatives.
Types of Congenital Heart Defects
In order to fully appreciate how congenital heart defects can impair the muscle's ability to perform its job, it is worth reviewing how the heart normally functions. There are four chambers - two upper chambers (atria) and two lower chambers (ventricles). The left and right sides have specific tasks. The right side sends oxygen-poor blood into the lungs to be oxygenated. That blood, rich with oxygen, returns through the left side before being sent into the aorta and throughout your body.
Repairing Versus Replacing Your Mitral Valve
Your heart has four distinct valves that help regulate the direction of your blood as it flows through the organ. They are the mitral, tricuspid, aortic, and pulmonary valves. They open and close as the result of pressure placed upon them. Your mitral valve (MV) sits between your left atrium and left ventricle. Pressure is placed upon it by each chamber's contractions, which cause the leaflets to open and close according to your heart's rhythm.
Common Questions About Minimally Invasive Mitral Valve Repair
Your mitral valve sits between your heart's left atrium and left ventricle. It regulates the flow of blood between the two chambers. As electrical signals from the sinus node cause the atrium to contract, the valve opens to allow blood to flow into the ventricle. Then, it closes again to seal the opening and prevent backflow.
How an Aortic Aneurysm is Treated
Your aorta is the largest blood vessel in your body. It begins from your heart's left ventricle and extends to your abdomen, after which it divides into two smaller arteries. If the walls of this blood vessel weaken (for example, due to atherosclerosis or high blood pressure), you may suffer an aortic aneurysm. There are two varieties: abdominal and thoracic.
Benefits of Cholesterol Lowering Supplements
Cholesterol is a substance produced by human liver. The body produces cholesterol to build acids to digest. It also serves as building and repairing cells. It also has influence in the process of production of hormones estrogen and testosterone.
What is the Definition of Cardiovascular Health and Why is Cardiovascular Health Important?
Cardiovascular health is a perfectly functioning heart and connected blood vessels that include, arteries, veins, capillaries and valves. All these put together form the cardiovascular system in the body and together they are responsible for transporting blood and nutrients to the various parts of the body and carrying back waste products from the organs to other organs to get the blood cleaned.
Heart Diseases - 4 Things You Should Know to Keep Your Heart Healthy
Heart disease is the leading cause of death in the world especially in America. More than 25% of all deaths are caused by heart disease. The risk of heart disease increases as you become older.
High Cholesterol is Not the Leading Cause of Heart Disease
Growing amounts of research suggest that chronic inflammation is the underlying cause of heart disease. Find out more about this condition and what you can do about it.
 
 
 
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